Metabolic pathway
Oxidative decarboxylation
The bridge between glycolysis and the Krebs cycle. It turns pyruvate into acetyl-CoA, losing one carbon as CO₂. It is irreversible, and that irreversibility explains why fatty acids cannot yield glucose.
- In
- Pyruvate + Coenzyme A + NAD⁺
- Out
- Acetyl-CoA + Carbon dioxide + NADH + Proton
- Location
- Mitochondrial matrix
Fun facts
- Pyruvate dehydrogenase complexIt is not one enzyme but a complex of three, with sixty subunits and five different coenzymes. It is bigger than a ribosome.
Reactions
| # | Enzyme | ΔG°′ |
|---|---|---|
| 1 | Pyruvate dehydrogenase complexEC 1.2.4.1 · irreversiblePyruvate + Coenzyme A + NAD⁺ → Acetyl-CoA + Carbon dioxide + NADH + Proton | −33.4kJ/molexergonic |
1 of 1 reactions with a documented ΔG.
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The data sheet includes the map. The logo goes at the bottom.
Sources
- Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 16