Pyruvate dehydrogenase complex EC 1.2.4.1

Links glycolysis to the Krebs cycle. It pulls one carbon off pyruvate as CO₂ and hooks the remaining two onto coenzyme A. It is irreversible, and that is why fatty acids cannot be turned into glucose.

exergonic
irreversible
Mitochondrial matrix

in depth

ΔG°′: −33.4 kJ/mol
Cofactors: Magnesium
Inhibited by: ATP
Inhibited by: NADH
Inhibited by: Acetyl-CoA
Location: Mitochondrial matrix

Fun fact

It is not one enzyme but a complex of three, with sixty subunits and five different coenzymes. It is bigger than a ribosome.

Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 16

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Oxidative decarboxylationPyruvate dehydrogenase complex

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