Glycogenesis · reaction 4 of 4

UDP-glucose → Glycogen (glucose residue) + UDP

Glycogen synthase EC 2.4.1.11

Releases the glucose from the nucleotide and adds it to the end of a glycogen chain that already exists. The enzyme lengthens, but it cannot start from scratch.

exergonic
irreversible
Cytosol

in depth

ΔG°′: −13.4 kJ/mol
Activated by: Glucose 6-phosphate
Location: Cytosol

Fun fact

The starting chain is made by glycogenin, a protein that attaches the first eight sugars to itself and then stays inside the granule, like the core of a ball of yarn.

Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 15

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