Glycolysis · reaction 5 of 10

Dihydroxyacetone phosphate ⇌ Glyceraldehyde 3-phosphate

Triose phosphate isomerase EC 5.3.1.1

Converts dihydroxyacetone phosphate into glyceraldehyde-3-phosphate, the only one of the two trioses the pathway can keep processing. Thanks to this all six carbons are used, not just three.

endergonic
Cytosol

in depth

ΔG°′: 7.5 kJ/mol
ΔG in the cell: 2.5 kJ/mol
Location: Cytosol

Fun fact

It is a catalytically perfect enzyme: its speed is limited not by its chemistry but by the diffusion of the substrate to the active site. It cannot go any faster.

Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 14

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GlycolysisTriose phosphate isomerase

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