Metabolic pathway
Glycogenolysis
Takes glycogen apart sugar by sugar to keep blood glucose up between meals. In the liver the glucose goes out into the circulation; in muscle it stays inside and is burned.
- In
- Glycogen (glucose residue) + Water
- Out
- Glucose
- Location
- Cytosol
Fun facts
- Glycogen phosphorylaseIt is the enzyme with which Carl and Gerty Cori described the first known hormonal cascade: adrenaline does not touch it, but activates a chain of messengers that ends up phosphorylating it.
Reactions
| # | Enzyme | ΔG°′ |
|---|---|---|
| 1 | Glycogen phosphorylaseEC 2.4.1.1Glycogen (glucose residue) + Inorganic phosphate ⇌ Glucose 1-phosphate | 3.1kJ/molendergonic |
| 2 | PhosphoglucomutaseEC 5.4.2.2Glucose 1-phosphate ⇌ Glucose 6-phosphate | −7.3kJ/molexergonic |
| 3 | Glucose-6-phosphataseEC 3.1.3.9 · irreversibleGlucose 6-phosphate + Water → Glucose + Inorganic phosphate | −13.8kJ/molexergonic |
3 of 3 reactions with a documented ΔG.
Use Shift to select several
The data sheet includes the map. The logo goes at the bottom.
Sources
- Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 15