Glycogen (glucose residue) + Inorganic phosphate ⇌ Glucose 1-phosphate

Glycogen phosphorylase EC 2.4.1.1

Cuts the last sugar off the chain with phosphate instead of water. The glucose comes out already phosphorylated, so the cell saves the ATP it would cost to phosphorylate it later.

endergonic
Cytosol

in depth

ΔG°′: 3.1 kJ/mol
Activated by: AMP
Inhibited by: ATP
Inhibited by: Glucose 6-phosphate
Location: Cytosol

Fun fact

It is the enzyme with which Carl and Gerty Cori described the first known hormonal cascade: adrenaline does not touch it, but activates a chain of messengers that ends up phosphorylating it.

Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 15

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GlycogenolysisGlycogen phosphorylase

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