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Gluconeogenesis · reaction 2 of 11

Oxaloacetate + GTP → Phosphoenolpyruvate + Carbon dioxide + GDP

Phosphoenolpyruvate carboxykinase EC 4.1.1.32

Removes the carbon that had just been added and, with the energy of a GTP, leaves phosphoenolpyruvate. Adding and removing the same carbon looks like a waste, but it is what makes the energy jump possible.

endergonic
irreversible
Cytosol

in depth

ΔG°′: 0.9 kJ/mol
Location: Cytosol

Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 15

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GluconeogenesisPhosphoenolpyruvate carboxykinase

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