Phosphoenolpyruvate + Water ⇌ 2-Phosphoglycerate

Enolase EC 4.2.1.11

Gives the water back to the molecule. From here up to fructose bisphosphate, gluconeogenesis uses the same enzymes as glycolysis in the opposite direction: they are reversible and no detours are needed.

exergonic
Cytosol

in depth

ΔG°′: −1.8 kJ/mol
Location: Cytosol

Nelson, D. L. & Cox, M. M. (2021). Lehninger. Principios de bioquímica, 8.ª ed., ch. 14

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GluconeogenesisEnolase

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